x402basequality 0.82

Discover rising sub-topics within any biomedical research field via multi-year growth analysis from OpenAlex data.

Price
per_call
Protocol
x402
Verified
no
Endpoint
https://pubmed.sekgen.xyz/api/v1/trending-subtopics

What it does

The trending-subtopics endpoint at pubmed.sekgen.xyz identifies which sub-topics within a given research field are growing fastest. It draws on OpenAlex topic breakdowns to compute compound annual growth rates (CAGR) over a configurable 2–5 year window, returning ranked results with per-year publication counts, growth scores, and trend direction. The endpoint accepts a free-text query defining the field (e.g. "ulcerative colitis", "CRISPR", "cardiology") and returns up to 25 sub-topics sorted by growth.

Payment is handled via the x402 protocol: the server responds with HTTP 402 and a payment challenge; an x402-compatible client signs a USDC transfer on Base L2 and retries with proof. The cost is $0.05 per query. No API keys or subscriptions are required. Responses are structured JSON designed for LLM agents and data pipelines.

The service is part of a broader PubMed Trends API suite covering 11 endpoints (trends, compare, emerging, hottest-weekly, pulse, snapshot, keypapers, digest, explore, author, and this one). Data is sourced from NCBI PubMed (36M+ articles) and OpenAlex. The trending-subtopics endpoint is specifically powered by OpenAlex and is useful for grant writing, biotech due diligence, research surveillance, and identifying niche growth areas within established fields.

Capabilities

pubmed-analyticsopenalex-topic-breakdownsubtopic-growth-detectioncagr-calculationmulti-year-trend-windowbiomedical-research-trendsx402-paymentusdc-on-basejson-responseagent-native

Use cases

  • —Identify which sub-specialties within oncology or neuroscience are gaining traction for grant proposals
  • —Monitor a therapeutic area for rising sub-topics as part of a weekly research surveillance pipeline
  • —Evaluate the scientific momentum behind a biotech company's focus areas during due diligence
  • —Help a principal investigator build the Significance section of a grant application with data-backed emerging trends
  • —Feed an LLM agent with structured growth data to generate research landscape summaries

Fit

Best for

  • —AI agents needing structured biomedical trend data without API key management
  • —Biotech analysts performing scientific due diligence on emerging sub-fields
  • —Grant writers who need quantitative evidence of topic growth
  • —Research teams running automated surveillance on specific therapeutic domains

Not for

  • —Full-text article retrieval or abstract access (use PubMed MCP or E-utilities for that)
  • —Real-time clinical decision support or patient-facing applications
  • —Non-biomedical research domains outside PubMed/OpenAlex coverage

Quick start

# Using an x402-compatible client (e.g. Coinbase awal):
awal x402 pay 'https://pubmed.sekgen.xyz/api/v1/trending-subtopics?query=ulcerative+colitis&limit=10'
# Pays $0.05 USDC on Base → returns rising sub-topics with CAGR and counts

Example

Request

{
  "url": "https://pubmed.sekgen.xyz/api/v1/trending-subtopics?query=ulcerative+colitis&limit=10&window=3",
  "method": "GET"
}

Response

{
  "as_of": "2026-02-22",
  "query": "ulcerative colitis",
  "results": [
    {
      "cagr": 0.102,
      "counts": {
        "2022": 276,
        "2023": 301,
        "2024": 335
      },
      "topic_id": "T13569",
      "topic_name": "Microscopic Colitis",
      "growth_score": 0.257,
      "trend_direction": "growing",
      "latest_year_count": 335
    }
  ],
  "window_years": 3,
  "total_topics_found": 162
}

Endpoint

URLhttps://pubmed.sekgen.xyz/api/v1/trending-subtopics
Transporthttp
Protocolx402
Pay to0x8C05121C9617f8960Cf5b7451103192F32DE8ddE
CurrencyUSD COIN

Quality

0.82/ 1.00

The endpoint is live (402 challenge captured), documentation is thorough with parameter tables, example requests, and example responses. No formal OpenAPI schema is published, but the docs page provides equivalent detail. Price is clearly stated at $0.05 USDC.

Warnings

  • —No formal OpenAPI/JSON schema file was found; documentation is HTML-based only
  • —The /pricing and /README paths return 404; pricing info is only on the landing page and docs

Citations

Provenance

Indexed fromx402_bazaar
Enriched2026-04-22 01:15:51Z · anthropic/claude-opus-4.6 · v2
First seen2026-04-21
Last seen2026-04-22

Agent access

JSONhttps://clawmart.sh/api/listings/zpMmmP
Discover rising sub-topics within any biomedical research field via multi-year growth analysis from OpenAlex data. — Clawmart · Clawmart