{"id":"dbfc6a41-80e7-4893-bbba-32aba4c801c6","shortId":"XQRjeq","kind":"x402","title":"Year-by-year PubMed publication trends, growth analytics, and CAGR for any biomedical topic — $0.01/query via x402.","tagline":"Year-by-year PubMed publication trends, growth analytics, and CAGR for any biomedical topic — $0.01/query via x402.","description":"The PubMed Trends API at pubmed.sekgen.xyz provides programmatic access to publication trend analytics drawn from over 36 million PubMed articles and OpenAlex data. It exposes 11 endpoints covering year-by-year publication counts, multi-term comparisons, emerging topic detection, weekly spike rankings, sub-topic breakdowns, key paper scoring, author profiles, and more. All responses are JSON, designed for LLM agents and data pipelines rather than dashboards.\n\nPayment is per-query via the x402 protocol using USDC on Base L2 (also supports MPP on Tempo). Prices range from $0.01 for a simple trend lookup or snapshot to $0.10 for cross-domain discovery. No API keys or subscriptions are required — an agent sends a standard HTTP request, receives a 402 challenge with payment instructions, signs a USDC transfer, and retries with proof to receive data.\n\nThe `/trends` endpoint specifically returns year-by-year publication counts for any PubMed search query, along with computed analytics including CAGR, peak year, trend direction, and acceleration. Optional parameters let you set a custom year range. Other endpoints in the suite let you compare terms head-to-head (`/compare`), detect real-time surges (`/pulse`, `/hottest-weekly`), find emerging niche topics (`/emerging`), discover anomalies across MeSH categories (`/explore`), and retrieve scored key papers with PMIDs (`/keypapers`, `/digest`). Data sources include NCBI PubMed and OpenAlex.","tags":[],"capabilities":["pubmed-search","publication-trend-analysis","year-over-year-growth","cagr-calculation","emerging-topic-detection","weekly-spike-ranking","multi-term-comparison","key-paper-scoring","mesh-anomaly-detection","author-profile-lookup","openalex-integration","x402-payment","usdc-on-base"],"categories":["research","bio","data"],"synonyms":["PubMed analytics","biomedical research trends","publication growth rate","scientific literature trends","PubMed CAGR","medical research analytics","literature surveillance","bibliometric API","research trend tracker"],"warnings":["No formal OpenAPI/JSON schema published — endpoint contracts are documented in prose/tables only","The probe used POST but docs specify GET for /trends; the endpoint accepted both with a 402 challenge","No /pricing or /README pages found (404); all pricing info comes from the landing page and /docs"],"endpointUrl":"https://pubmed.sekgen.xyz/api/v1/trends","protocol":"x402","transport":"http","auth":{"type":"x402","details":[{"asset":"0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913","extra":{"name":"USD Coin","version":"2"},"payTo":"0x8C05121C9617f8960Cf5b7451103192F32DE8ddE","amount":"10000","scheme":"exact","network":"eip155:8453","maxTimeoutSeconds":300}]},"qualityScore":"0.880","qualityRationale":"The endpoint is live (402 challenge captured), documentation is thorough with parameter tables and example responses for all endpoints, pricing is clearly stated, and the landing page provides use-case examples. No formal OpenAPI schema is published, which prevents a perfect score, but the docs are detailed enough to be functionally 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