{"id":"1e6fbbd8-bb72-4122-af50-cc56035e531d","shortId":"BRArbJ","kind":"x402","title":"Pay-per-query research trend analytics from 36M+ PubMed articles via x402/MPP in USDC.","tagline":"Pay-per-query research trend analytics from 36M+ PubMed articles via x402/MPP in USDC.","description":"PubMed Trends API provides publication trend analytics drawn from over 36 million PubMed articles and OpenAlex data. It exposes 11 GET endpoints covering year-by-year trend analysis, cross-term comparison, emerging topic detection, weekly spike ranking, sub-topic discovery, recent publication pulse, key paper scoring, researcher profiles, and more. All endpoints are JSON-first and designed for LLM agents and data pipelines rather than dashboards.\n\nPayment is handled per-query via the x402 protocol (USDC on Base L2) or MPP (USDC on Tempo). Prices range from $0.01 for a simple snapshot or trend query up to $0.10 for cross-domain exploration. No API keys or subscriptions are required — an agent sends a standard HTTP GET, receives a 402 challenge with payment instructions, signs a USDC transfer, and retries with proof to receive data.\n\nThe API supports two data sources: PubMed (via NCBI) for MeSH-based category queries and OpenAlex for free-text topic searches. Endpoints return structured JSON with metrics like CAGR, spike ratios, year-over-year growth, z-scores, and scored paper lists with PMIDs. Use cases include automated weekly research surveillance, biotech due diligence, grant writing support, and single-call lookups for trending topics. The service pairs with Anthropic's PubMed MCP for a trend-to-abstract workflow in as few as three calls.","tags":[],"capabilities":["pubmed-search","publication-trends","emerging-topic-detection","weekly-spike-ranking","term-comparison","researcher-profile","key-paper-scoring","mesh-anomaly-detection","openalex-integration","year-over-year-analysis","x402-payment","mpp-payment","usdc-on-base","json-api"],"categories":["research","bio","search"],"synonyms":["PubMed analytics","biomedical literature trends","research trend API","publication growth analytics","PubMed CRISPR trends","scientific literature monitoring","OpenAlex API","MeSH anomaly detection","biomedical research intelligence"],"warnings":["Probe returned 404 on both GET and POST — the endpoint /api/v1/hottest does not appear to exist. The documented endpoint is /api/v1/hottest-weekly.","No x402 402 challenge was captured during probing, so live payment flow could not be verified for this specific URL.","No OpenAPI/JSON schema is published; documentation is HTML only.","No /pricing page found (404); prices are only listed on the docs and landing pages."],"endpointUrl":"https://pubmed.sekgen.xyz/api/v1/hottest","protocol":"x402","transport":"http","auth":{"type":"x402","details":[{"asset":"0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913","extra":{"name":"USD Coin","version":"2"},"payTo":"0x8C05121C9617f8960Cf5b7451103192F32DE8ddE","amount":"50000","scheme":"exact","network":"eip155:8453","maxTimeoutSeconds":300}]},"qualityScore":"0.550","qualityRationale":"The landing page and docs are detailed with endpoint descriptions, parameters, example responses, and pricing. However, the probe returned 404 on both GET and POST for this specific endpoint (/api/v1/hottest), which does not match any documented endpoint (the documented variant is /api/v1/hottest-weekly). No 402 challenge was captured, and no OpenAPI schema is available. The endpoint as listed appears to be an incorrect 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'https://pubmed.sekgen.xyz/api/v1/trends?query=CRISPR&start_year=2018&end_year=2025'","exampleRequest":null,"exampleResponse":{"data":[{"year":2024,"count":8764,"proportion":0.00504,"yoy_growth":0.074,"total_pubmed":1737687}],"query":"CRISPR","end_year":2025,"analytics":{"cagr":0.052,"peak_year":2024,"peak_count":8764,"acceleration":0,"trend_direction":"growing"},"start_year":2018,"total_results":48523},"schema":null,"openapiUrl":null,"agentsTxtUrl":null,"citations":[{"claim":"The API covers 36M+ PubMed articles with trend analytics","source_url":"https://pubmed.sekgen.xyz"},{"claim":"11 endpoints ranging from $0.01 to $0.10 per query in USDC","source_url":"https://pubmed.sekgen.xyz/docs"},{"claim":"Payment via x402 (USDC on Base L2) or MPP (USDC on Tempo)","source_url":"https://pubmed.sekgen.xyz"},{"claim":"The documented weekly spike endpoint is /api/v1/hottest-weekly, not /api/v1/hottest","source_url":"https://pubmed.sekgen.xyz/docs"},{"claim":"Pairs with Anthropic's PubMed MCP for 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